反应 #2314326

反应方程式

iso-butylamine

diethyl DL-malate

diethyl DL-malate

iso-butylamine

→

N,N′-Di-iso-butyl DL-malamide

收率 29.0%

反应条件

后处理

1. 1
   其他had precipitated from solution
2. 2
   过滤The solid was filtered
3. 3
   洗涤washed with hexane (3×25 mL)
4. 4
   其他dried under vacuum (1.96 g, 29% yield)

实验过程

N,N′-Di-iso-butyl DL-malamide was prepared by the reaction of iso-butylamine with diethyl DL-malate. To a round-bottomed flask were added diethyl DL-malate (5.229 g, 1 eq) and iso-butylamine (14.058 g, 7 eq). The clear light yellow solution was stirred for 24 hours at room temperature, after which point a white solid had precipitated from solution. The solid was filtered, washed with hexane (3×25 mL), and dried under vacuum (1.96 g, 29% yield). The product was >99% pure as determined by NMR analyses.

来源