反应 #2314314

反应方程式

2-ethylbicyclo[2.2.1]heptan-2-ol

p-toluenesulfonic acid monohydrate

→

2-ethylidenebicyclo[2.2.1]heptane

收率 78.9%

溶剂

benzene

反应条件

后处理

1. 1
   温度This reaction mixture was heated
2. 2
   温度under reflux for 6 hours
3. 3
   其他while removing water
4. 4
   其他The resulting oily substance was purified by silica gel column chromatography

实验过程

In 600 ml of benzene was dissolved 125.0 g of 2-ethylbicyclo[2.2.1]heptan-2-ol in endo-form. To the solution was added 8.5 g of p-toluenesulfonic acid monohydrate. This reaction mixture was heated, agitated under reflux for 6 hours while removing water, and subjected to conventional post-treatment. The resulting oily substance was purified by silica gel column chromatography, obtaining 85.9 g of 2-ethylidenebicyclo[2.2.1]heptane. The yield was 78.8%.

来源