反应 #2314310

反应方程式

9H-tribenz[b,d,f]azepine

1,4-dibromobenzene

potassium hydroxide

→

9-(4-bromophenyl)-9H-tribenz[b,d,f]azepine

收率 25.1%

溶剂

decalin

反应条件

后处理

1. 1
   其他the resulting crude product was purified by silica gel column chromatography

实验过程

A mixture of 9.2 g (38 mmol) of 9H-tribenz[b,d,f]azepine (synthesized in accordance with J. Org. Chem., vol. 56, p. 3906 (1991)), 44.8 g (190 mmol) of 1,4-dibromobenzene, 5.6 g (100 mmol) of potassium hydroxide, 1.6 g (25 mmol) of copper powder, and 50 ml of decalin was heated at an external temperature of 200° C. for 36 hours in a nitrogen stream while stirring. The reaction mixture was worked up in the same manner as in Example 1, and the resulting crude product was purified by silica gel column chromatography to give 3.8 g (25%) of 9-(4-bromophenyl)-9H-tribenz[b,d,f]azepine.

来源