反应 #2314293

反应方程式

alcohol

4-Methyl-3-cyclohexenol

p-toluenesulfonyl chloride

HCl

→

4-Methyl-3-cyclohexenol tosylate

溶剂

pyridine

反应条件

后处理

1. 1
   workup.WAITto stand at −20° C. for a further 16 hours
2. 2
   萃取extracted with ethyl acetate
3. 3
   萃取The combined organic layers are extracted with brine
4. 4
   干燥dried over sodium sulfate
5. 5
   其他The solvent is removed in vacuo

实验过程

To a solution of alcohol 4C (R=methyl) (10 g) and p-toluenesulfonyl chloride (20.8 g) in anhydrous tetrahydrofaran (21 mL) at 0° C. is added anhydrous pyridine (21 mL). The reaction is allowed to stir in an ice bath for 2 hours, and is then allowed to stand at −20° C. for a further 16 hours. The reaction mixture is then poured into 2M HCl (75 mL) and extracted with ethyl acetate. The combined organic layers are extracted with brine and dried over sodium sulfate. The solvent is removed in vacuo.

来源