反应 #2314287

反应方程式

3-(4-hydroxyphenyl)-1-propanol

tetrabromomethane

water

→

1-(4′-hydroxyphenyl)-3-bromopropane

溶剂

dichloromethane

dichloromethane

反应条件

后处理

1. 1
   workup.ADDITIONis added
2. 2
   萃取extracted with ethyl acetate
3. 3
   洗涤The combined organic layers are washed with brine
4. 4
   干燥dried over magnesium sulfate
5. 5
   浓缩The solution is concentrated in vacuo

实验过程

To a solution of 3-(4-hydroxyphenyl)-1-propanol 3A (4.0 g) and tripohenylphosphine (7.96 g) in anhydrous dichloromethane (77 mL), cooled to 0° C., is added, dropwise, a solution of tetrabromomethane (9.59 g) in anhydrous dichloromethane (15.4 mL). The reaction mixture gradually warmed to room temperature and allowed to stir overnight. The solution is then poured into water and extracted with ethyl acetate. The combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

来源