反应 #2314281

反应方程式

hydrochloric acid

sodium hydroxide

nitrile

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

water

→

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetic acid

溶剂

hydrogen peroxide

反应条件

后处理

1. 1
   温度at reflux overnight
2. 2
   萃取The acid product is extracted with ethyl acetate
3. 3
   洗涤the combined organic layers are washed with brine
4. 4
   干燥dried over magnesium sulfate
5. 5
   浓缩The solution is concentrated in vacuo

实验过程

To a solution of sodium hydroxide (10.5 g) in water (150 mL) and 30% hydrogen peroxide (50 mL) is added the nitrile 2A (R=4-Methyl-3-pentenyl) (10 g). The reaction mixture is stirred at reflux overnight. The reaction is then cooled to room temperature, and poured into a mixture of ice (30 g) and hydrochloric acid (22 mL). The acid product is extracted with ethyl acetate, and the combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

来源