反应 #2314280

反应方程式

water

tosylate

potassium cyanide

→

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

溶剂

dimethylsulfoxide

反应条件

后处理

1. 1
   温度The reaction mixture is cooled to room temperature
2. 2
   萃取extracted with hexane
3. 3
   干燥The combined organic layers are dried over magnesium sulfate
4. 4
   浓缩the solution is concentrated in vacuo

实验过程

To a solution of tosylate 1H (R=4-Methyl-3-pentenyl) (20 g) in dimethylsulfoxide (178 mL) is added potassium cyanide (19.4 g). The reaction mixture is heated to 100° C., and the reaction mixture is stirred at that temperature for three hours. The reaction mixture is cooled to room temperature, added to water (300 mL), and extracted with hexane. The combined organic layers are dried over magnesium sulfate and the solution is concentrated in vacuo.

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