反应 #2314278

反应方程式

tetrabromomethane

3-(4-hydroxyphenyl)-1-propanol

triphenylphosphine

→

3-(4-hydroxyphenyl)-1-bromopropane

收率 62.0%

溶剂

dichloromethane

dichloromethane

反应条件

后处理

1. 1
   萃取extracted with dichloromethane
2. 2
   洗涤the organic layer was washed with water
3. 3
   干燥dried over anhydrous magnesium sulfate
4. 4
   其他The solvent was removed in vacuo
5. 5
   其他the crude reaction mixture
6. 6
   过滤was filtered through silica gel
7. 7
   洗涤eluting with 10% ethyl acetate in hexane

实验过程

A solution of tetrabromomethane (1.125 eq.) in dichloromethane (0.5 ml/mole) was added dropwise to the solution of the commercially available 3-(4-hydroxyphenyl)-1-propanol 1B (1 eq.) and triphenylphosphine (1.125 eq.) in dichloromethane at 0° C. The reaction mixture was stirred at room temperature for 2 days, extracted with dichloromethane, and the organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed in vacuo. the crude reaction mixture was filtered through silica gel, eluting with 10% ethyl acetate in hexane, to give 3-(4-hydroxyphenyl)-1-bromopropane 2 as a brown oil in 62% yield.

来源