反应 #2307995

ord-9c36f46bb6dc4fe88f248e6d2b99d251

反应方程式

CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O
N-(tert-Butoxycarbonyl)-D-leucine
CCC[C@H](N)C(=O)OC.Cl
methyl L-norvalinate hydrochloride
→
CCC[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)OC(C)(C)C)C(=O)OC
Methyl N-(tert-butoxycarbonyl)-D-leucyl-L-norvalinate

反应物

CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O
N-(tert-Butoxycarbonyl)-D-leucine
CCC[C@H](N)C(=O)OC.Cl
methyl L-norvalinate hydrochloride

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他The crude product is purified by workup method 1
  2. 2
    其他The product is obtained in quantitative yield

实验过程

N-(tert-Butoxycarbonyl)-D-leucine (1000 mg, 4.32 mmol) and methyl L-norvalinate hydrochloride (1090 mg, 6.49 mmol) are reacted by general procedure 6. The crude product is purified by workup method 1. The product is obtained in quantitative yield.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07368424B2uspto-grants-2008_05