反应 #2307994

ord-2babaaee8faa4a2e924b9afd581c7aec

反应方程式

CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O
N-(tert-Butoxycarbonyl)-D-leucine
Cl.N[C@@H](CC1CC1)C(=O)OCc1ccccc1
benzyl 3-cyclopropyl-L-alaninate hydrochloride
CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC1CC1)C(=O)OCc1ccccc1
Benzyl N-(tert-butoxycarbonyl)-D-leucyl-3-cyclopropyl-L-alaninate

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他The crude product is purified by preparative HPLC, (method 16),
  2. 2
    其他resulting in a quantitive yield of the product

实验过程

N-(tert-Butoxycarbonyl)-D-leucine (540 mg, 2.32 mmol) and benzyl 3-cyclopropyl-L-alaninate hydrochloride (Example 3A, 490 mg, 1.93 mmol) are reacted by general procedure 6. The crude product is purified by preparative HPLC, (method 16), resulting in a quantitive yield of the product.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07368424B2uspto-grants-2008_05