反应 #2307985

反应方程式

4-(2,6,6-trimethyl-cyclohex-1-enyl)-butan-2-one

sodium sulfate

3-amino-1-propanol

→

2-Methyl-2-[2-(2,6,6-trimethyl-cyclohex-1-enyl)-ethyl]-[1,3]oxazinane

溶剂

methanol

反应条件

后处理

1. 1
   温度is cooled to 0° C.
2. 2
   其他the solids are removed via vacuum filtration through Celite
3. 3
   其他Evaporation of the solvent
4. 4
   其他gives a clear yellow oil

实验过程

To a 0° C. stirred solution of 4-(2,6,6-trimethyl-cyclohex-1-enyl)-butan-2-one (25.2 g, 0.13 mol) and sodium sulfate (20 g) in 80 mL of methanol is added 3-amino-1-propanol (10 g, 0.13 mol). The reaction is allowed to warm to room temperature. After stirring for 24 h the mixture is cooled to 0° C. and the solids are removed via vacuum filtration through Celite. Evaporation of the solvent gives a clear yellow oil.

来源