反应 #2307970

ord-2f87d10f5782437c80dc87a956189339

反应方程式

Cc1ccc(CO)cc1C
3,4-dimethylbenzyl alcohol
Cc1ccc(C=O)cc1C
3,4-dimethylbenzaldehyde
Cc1ccc(C)c(C)c1
pseudocumene
Cc1ccc(C(=O)O)cc1C
3,4-dimethylbenzoic acid

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他11 hours
  2. 2
    浓缩the pseudocumene and 3,4-dimethylbenzyl alcohol concentrations

实验过程

FIG. 9 demonstrates the formation of 3,4-dimethylbenzyl alcohol commenced immediately. The formation of 3,4-dimethylbenzaldehyde commenced after 2 hours. 11 hours after starting the fed-batch culture, another 1% (v/v) of pseudocumene was added. However, only some of this substrate was now converted. The end concentration of 3,4-dimethylbenzylaldehyde was 113 mM. When the biotransformation was stopped, the pseudocumene and 3,4-dimethylbenzyl alcohol concentrations were 65 mM. Virtually no 3,4-dimethylbenzoic acid was produced.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07368267B2uspto-grants-2008_05