反应 #2307967

ord-84004a01edaa4803a8018f5eaee77331

反应方程式

CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine
CCCCCCCCCCCCCCCCCC(=O)O
stearic acid
→
CCCCCCCCCCCCCCCCCC(=O)O.CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine Stearic Acid

反应物

CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine
CCCCCCCCCCCCCCCCCC(=O)O
stearic acid

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    过滤sieved through a 120-mesh screen
  2. 2
    其他to obtain particles

实验过程

Equal amounts of Buprenorphine particles (prepared as described in Example 4) above) and stearic acid (prepared as described in Example 3) were blended and ground. The ground material was compressed in a 13-mm round die, with a force of 5,000 pounds for 5 minutes. Compressed tablets were ground and sieved through a 120-mesh screen followed by a 230-mesh screen to obtain particles having a size range between 63-125 microns.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07368126B2uspto-grants-2008_05