反应 #2298641

反应方程式

4-[2-[2-ethyl-4-methyl-6-oxo-1,6dihydro-1-pyrimidinyl]ethoxy]benzyl hydroxylamine

KOCN

→

compound

收率 85.2%

N-[4-[2-[2-Ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]benzyl]N-hydroxyurea

收率 85.2%

溶剂

water

acetic acid

water

water

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate (3×10 ml)
2. 2
   洗涤The combined organic layers were washed with brine
3. 3
   干燥dried over anhydrous Na2SO4
4. 4
   浓缩concentrated

实验过程

To a stirred solution of 4-[2-[2-ethyl-4-methyl-6-oxo-1,6dihydro-1-pyrimidinyl]ethoxy]benzyl hydroxylamine (303 mg, 1.0 mmol) (obtained from preparation 18) in a mixture of water (2 ml) and acetic acid (0.5 ml) was added a solution of KOCN (343 mg, 3.0 mmol) in water (1 ml) and stirred for 1 h at 30° C. The reaction mixture was diluted with water and extracted with ethyl acetate (3×10 ml). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated to yield the compound (295 mg, 85%).

来源