反应 #2298613

反应方程式

acetic anhydride

methyl 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

→

3-(formylamino)-4-methyl-2-thiophenecarboxylic acid methyl ester

收率 95.0%

溶剂

Formic acid

反应条件

后处理

1. 1
   温度while cooling in an ice bath
2. 2
   其他The cooling bath was removed
3. 3
   workup.ADDITIONThe reaction mixture was diluted with water (100 mL)
4. 4
   过滤the solid product collected by vacuum filtration

实验过程

Formic acid (53 mL) was added to acetic anhydride (53 mL) while cooling in an ice bath. Solid methyl 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester (1, 18.2 g, 0.11 mol) was added to the cold solution in small portions. The cooling bath was removed and the resulting suspension was stirred at room temperature for 4 hours. The reaction mixture was diluted with water (100 mL) and the solid product collected by vacuum filtration to yield 3-(formylamino)-4-methyl-2-thiophenecarboxylic acid methyl ester (20.2 g, 95% yield) as a white solid.

来源