反应 #2286361

反应方程式

1,1,1-tri acetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one

tert-butyl 4-[4-(1-hydroxy-3-phenylpropyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

→

tert-Butyl 4-[4-(3-phenylpropanoyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

溶剂

dichloromethane

反应条件

后处理

1. 1
   workup.ADDITION5 g of silica gel were then added
2. 2
   其他the solvent was removed under reduced pressure
3. 3
   其他The residue was purified chromatographically

实验过程

At room temperature, 1,1,1-tri acetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one (15% strength solution in dichloromethane, 8.3 g) was added dropwise to a solution of tert-butyl 4-[4-(1-hydroxy-3-phenylpropyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate (790 mg) in dichloromethane (7.9 ml). The reaction mixture was stirred at room temperature overnight. 5 g of silica gel were then added, and the solvent was removed under reduced pressure. The residue was purified chromatographically. This gave tert-butyl 4-[4-(3-phenylpropanoyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate (545 mg).

来源