反应 #2271700

反应方程式

1,3-dibromopropane

N,N-dimethyl-4-hydroxy-3-methoxybenzamide

potassium carbonate

→

N,N-dimethyl-4-bromopropoxy-3-methoxybenzamide

收率 83.7%

溶剂

acetonitrile

反应条件

后处理

1. 1
   其他The resulting reaction mixture
2. 2
   温度was refluxed for 3 hours
3. 3
   过滤The mixture was filtered
4. 4
   浓缩concentrated to an oil
5. 5
   其他purification by column chromatography

实验过程

To N,N-dimethyl-4-hydroxy-3-methoxybenzamide (5.64 g, 28.7 mmol) in acetonitrile (450 ml) was added potassium carbonate (7.9 g) followed by 1,3-dibromopropane (11.6 g). The resulting reaction mixture was refluxed for 3 hours and stirred at room temperature for 12 hours. The mixture was filtered and concentrated to an oil. Following purification by column chromatography, N,N-dimethyl-4-bromopropoxy-3-methoxybenzamide as a colorless oil (7.6 g) was obtained.

来源