反应 #2271693

反应方程式

4-(3-chloropropoxy)-3-methoxybenzoic acid

thionyl chloride

→

4-(3-chloropropoxy)-3-methoxybenzoyl chloride

收率 60.8%

溶剂

dichloromethane

dichloromethane

反应条件

后处理

1. 1
   温度refluxed for 1 hour
2. 2
   其他the dichloromethane was removed in vacuo
3. 3
   其他to leave a dark oil
4. 4
   其他The oil was triturated with hexane
5. 5
   其他the solid that formed
6. 6
   其他was collected

实验过程

To a mixture of 4-(3-chloropropoxy)-3-methoxybenzoic acid (2.4 g, 10 mmol) in dichloromethane (5 ml) was added thionyl chloride (0.9 ml, 12 mmol) dissolved in dichloromethane (5 ml). The reaction was stirred and refluxed for 1 hour, and then the dichloromethane was removed in vacuo to leave a dark oil. The oil was triturated with hexane and the solid that formed while scratching with a glass rod was collected to afford 1.6 g of 4-(3-chloropropoxy)-3-methoxybenzoyl chloride, m.p.=60°-63° C.

来源