反应 #2271678

反应方程式

6-fluoro-3-(4-piperidinyl)-1H-indazole

K2CO3

1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone

acetonitrile

→

desired product

收率 80.8%

1-[4-[3-[4-(6-Fluoro-1H-indazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]-ethanone

收率 80.8%

溶剂

water

反应条件

后处理

1. 1
   其他the resulting white solid, which precipitated from solution
2. 2
   其他was collected

实验过程

A stirred mixture of 6-fluoro-3-(4-piperidinyl)-1H-indazole (3.5 g, 16 mmol). K2CO3 (2.2 g). 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone (3.8 g, 16 mmol) and acetonitrile (90 ml) was refluxed for 16 hours. The reaction was poured into water and the resulting white solid, which precipitated from solution, was collected to afford 5.5 g of the desired product. The compound was recrystallized from dimethylformamide (twice) to afford 3.0 g (44%) of 1-[4-[3-[4-(6-fluoro-1H-indazol-3-yl)-1-piperidinyl]propoxy]-methoxyphenyl]ethanone as a white solid, m.p.=202°-204° C.

来源