反应 #2267089

ord-f8c00701ed064db694c0e69151198392

反应方程式

CC(C)NC(C)C
Diisopropylamine
C=C1C(=O)O[C@H]2C[C@]3(C)O[C@H]3[C@@H]3O[C@@H]3C3=C[C@@H](OC3=O)[C@H]12
mikanolide
→
CC(C)N(CC1C(=O)OC2CC3(C)OC3C3OC3C3=CC(OC3=O)C21)C(C)C
product
收率 25.5%
CC(C)N(CC1C(=O)OC2CC3(C)OC3C3OC3C3=CC(OC3=O)C21)C(C)C
12-diisopropylaminomethyl-7-methyl-3.6,10,15-tetraoxapentacyclo[12.2.1.02,4.05,7.09,13]heptadec-1(17)-ene-11,16-dione
收率 25.5%

反应物

CC(C)NC(C)C
Diisopropylamine
C=C1C(=O)O[C@H]2C[C@]3(C)O[C@H]3[C@@H]3O[C@@H]3C3=C[C@@H](OC3=O)[C@H]12
mikanolide

试剂

无

溶剂

CC(C)=O
acetone

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他the solvent is eliminated by evaporation under reduced pressure
  2. 2
    过滤filtered
  3. 3
    其他dried under vacuum

实验过程

Diisopropylamine (500 μmol; 70 μl) is added to a solution of mikanolide (100 μmol; 29 mg) in acetone (1 ml). The reaction mass is stirred for 30 minutes at ambient temperature then the solvent is eliminated by evaporation under reduced pressure. The residue is taken up in ether, filtered and dried under vacuum. 10 mg of product is obtained in the form of a white powder.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06887869B2uspto-grants-2005_05