反应 #2267084

反应方程式

3-Methoxy-4-hydroxyphenylacetic acid propyl ester

3-methoxy-4-hydroxyphenylacetic acid propyl ester

K2CO3

2-chloro-N,N-diethylacetamide

→

dark yellow oil

收率 95.0%

[4-[(N,N-diethylcarbamoyl)methoxy]-3-methoxyphenyl]acetic Acid Propyl Ester

收率 95.0%

溶剂

acetone

反应条件

后处理

1. 1
   温度Under vigorous stirring, the suspension was warmed
2. 2
   温度After cooling to room temperature the reaction mixture
3. 3
   过滤was filtered
4. 4
   其他the remaining solvent removed under reduced pressure

实验过程

3-Methoxy-4-hydroxyphenylacetic acid propyl ester (15-A) was dissolved in acetone. To the solution, 2 equivalents of K2CO3 were added, followed by 1.2 equivalent of 2-chloro-N,N-diethylacetamide. Under vigorous stirring, the suspension was warmed to reflux (60° C.) for ˜15 hours. After cooling to room temperature the reaction mixture was filtered and the remaining solvent removed under reduced pressure, giving a 95% yield of a dark yellow oil. The oily product was purified by silica column chromatography to produce the title compound.

来源