反应 #2267083

反应方程式

4-Hydroxy-3-methoxyphenethyl alcohol

1-propanol

→

15-A

3-methoxy-4-hydroxyphenylacetic acid propyl ester

反应条件

后处理

1. 1
   其他the 1-propanol was removed under reduced pressure
2. 2
   workup.ADDITIONthe resulting oil was diluted with ethyl acetate
3. 3
   洗涤washed with saturated sodium bicarbonate solution
4. 4
   workup.DISTILLATIONdistilled water
5. 5
   干燥The solution was dried over magnesium sulfate
6. 6
   过滤filtered
7. 7
   其他the solvent was removed under reduced pressure

实验过程

4-Hydroxy-3-methoxyphenethyl alcohol (Sigma-Aldrich) was dissolved in anhydrous 1-propanol. To this solution ˜5 drops of concentrated sulphuric acid were added and the solution was heated at 100° C. for 3-5 hours in a pressure tube. When the reaction was complete, the 1-propanol was removed under reduced pressure, the resulting oil was diluted with ethyl acetate and washed with saturated sodium bicarbonate solution, distilled water, and then brine. The solution was dried over magnesium sulfate and filtered and the solvent was removed under reduced pressure, giving 15-A as a red oil in almost quantitative yield.

来源