反应 #2267082

反应方程式

compound 14

6-Acetylamino-3-methyl-1-(4-nitrophenyl)-7-methoxyisochroman

acetone

→

desired product

收率 82.0%

3-Acetylamino-4-methoxy-6-(4-nitrobenzoyl)-phenylacetone

收率 82.0%

溶剂

H2SO4

反应条件

后处理

1. 1
   萃取The solution was extracted with ethyl acetate three times
2. 2
   洗涤The combined organic phase was washed with brine
3. 3
   干燥by drying over Na2SO4
4. 4
   其他Removal of the solvent

实验过程

To a solution of compound 14 (0.375 g, 1.05 mmol) in 30 ml of acetone was added 3 ml of CrO3 in 35% H2SO4 at 0° C. The resulted solution was stirred another 2 h at same temperature. Ice water was added. The solution was extracted with ethyl acetate three times. The combined organic phase was washed with brine, followed by drying over Na2SO4. Removal of the solvent afforded the desired product in the yield of 82%. 1HNMR(CDCl3): 8.5-7.8 (m, 6H), 6.8 (s, 1H), 4.08 (s, 2H), 3.8 (s, 3H), 2.24 (s, 3H), 2.21 (s, 3H).

来源