反应 #2267081

反应方程式

Water

23

2′-Acetylamino-6′-(2-hydroxypropyl)-3′-methoxy-4-nitrobenzophenone acetylhydrazone

triethyl amine

methanesulfonyl chloride

→

product 24

2′-Acetylamino-6′-(2-methanesulfonyloxypropyl)-3′-methoxy-4-nitrobenzophenone acetylhydrazone

溶剂

CH2Cl2

反应条件

后处理

1. 1
   萃取extracted with CH2Cl2
2. 2
   洗涤The organic phase was washed with HCl (1N), brine
3. 3
   干燥dried over Na2SO4
4. 4
   其他Removal of the solvent

实验过程

To a solution of 23 (1.1 g) in 20 ml of CH2Cl2 was added 1.5 ml of triethyl amine, 0.60 ml of methanesulfonyl chloride at 0-10° C. After 30 min, no more starting material was detected on TLC. Water was added, extracted with CH2Cl2. The organic phase was washed with HCl (1N), brine, dried over Na2SO4. Removal of the solvent afforded product 24 (1.21 g).

来源