反应 #2267079

反应方程式

14

6-Acetylamino-3-methyl-1-(4-nitrophenyl)-7-methoxyisochroman

sodium hydroxide

HCl

→

22

6-Acetylamino-1-hydroxy-3-methyl-1-(4-nitrophenyl)-7-methoxyisochroman

溶剂

DMSO

DMF

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate three times
2. 2
   洗涤The combined organic phase was washed with water
3. 3
   干燥dried over Na2SO4
4. 4
   其他Removal of the solvent

实验过程

A solution of 14 (1.8 g) in 5 ml of DMSO and 30 ml of DMF was cooled to 8-12° C. and air was passed through the mixture. To the solution was added 1.2 ml of 50% aqueous sodium hydroxide in one portion and the resulting mixture was stirred for 5 hours. HCl (1 N) was added, and extracted with ethyl acetate three times. The combined organic phase was washed with water, dried over Na2SO4. Removal of the solvent afforded 22 (1.9 g) as a syrup, which was used directly for the next step.

来源