反应 #2267076

反应方程式

14

6-Acetylamino-3-methyl-1-(4-nitrophenyl)-7-methoxyisochroman

→

desired product 15

收率 100.0%

6-Amino-3-methyl-1-(4-nitrophenyl)-7-methoxyisochroman

收率 100.0%

溶剂

H2SO4

methanol

反应条件

后处理

1. 1
   温度After refluxing for 15 hours
2. 2
   其他the methanol was removed under reduced pressure
3. 3
   萃取followed by extraction with ethyl acetate three times
4. 4
   干燥The combined organic phase was dried over Na2SO4
5. 5
   其他Removal of the solvent

实验过程

Solution of 14 (0.114 g, 0.32 mmol) in 5 ml of 4N H2SO4 and 5 ml of methanol was heated to reflux. After refluxing for 15 hours, the methanol was removed under reduced pressure. The remaining aqueous solution was neutralized with NaHCO3 to pH 9, followed by extraction with ethyl acetate three times. The combined organic phase was dried over Na2SO4. Removal of the solvent afforded the desired product 15 (100 mg, 100%) which was used directly for next step.

来源