反应 #2267070

反应方程式

4

1-Hydroxy-3-methyl-1-(4-nitrophenyl)-6-methoxyisochroman

acetic hydrazide

→

desired product

收率 66.3%

6′-(2-Hydroxypropyl)-4′-methoxy-4-nitrobenzophenone acetylhydrazone

收率 66.3%

溶剂

ethanol

反应条件

后处理

1. 1
   温度The resulting solution was heated
2. 2
   温度to reflux for 3 hours
3. 3
   其他The solvent was removed under reduced pressure
4. 4
   workup.ADDITIONThe residue was treated with NaHCO3
5. 5
   萃取extracted with ethyl acetate
6. 6
   洗涤The combined organic phase was washed with brine
7. 7
   干燥dried over Na2SO4
8. 8
   其他Removal of the solvent

实验过程

To a solution of 4 (1.6 g) in 25 ml of ethanol was added acetic hydrazide (0.4 g) and 2 drops of concentrated HCl. The resulting solution was heated to reflux for 3 hours. The solvent was removed under reduced pressure. The residue was treated with NaHCO3, and extracted with ethyl acetate. The combined organic phase was washed with brine, dried over Na2SO4. Removal of the solvent gave the desired product (1.25 g).

来源