反应 #2267067

反应方程式

3-methoxyphenylacetone

NaBH4

→

desired product 2

收率 100.0%

1-(3-Methoxyphenyl)-2-propyl alcohol

收率 100.0%

溶剂

methanol

反应条件

后处理

1. 1
   萃取It was extracted with CHCl3 three times
2. 2
   洗涤The combined organic phase was washed with brine
3. 3
   干燥dried over Na2SO4
4. 4
   其他Removal of the solvent
5. 5
   其他afforded the crude product
6. 6
   其他Purification of the crude product

实验过程

To a solution of 3-methoxyphenylacetone (1, 1.0 g) in methanol (30 ml) was added NaBH4 (360 mg) in portions in the period of 20 min at 0° C. The resulting solution was stirred at such temperature for another 40 min. No more starting materials were detected from TLC. Ice water was added to the reaction slowly. It was extracted with CHCl3 three times. The combined organic phase was washed with brine, and dried over Na2SO4. Removal of the solvent afforded the crude product. Purification of the crude product by using a silica gel column gave the desired product 2 (1.01 g, 100%).

来源