反应 #2267053

反应方程式

propyl bromide

8,9-difluoro-3-methyl-1,2,3,4-tetrahydro-1-oxaanthracene

n-butyllithium

potassium tert-butoxide

→

8,9-difluoro-3-methyl-7-propyl-1,2,3,4-tetrahydro-1-oxaanthracene

收率 23.7%

溶剂

tetrahydrofuran

tetrahydrofuran

反应条件

后处理

1. 1
   workup.WAITAfter 2 h
2. 2
   温度the temperature was cooled to −70° C.
3. 3
   workup.STIRRINGthe mixture was stirred at this temperature for a further 1 h
4. 4
   workup.WAITto come to 0° C. overnight
5. 5
   萃取extracted twice with 100 ml each time of tert-butyl methyl ether
6. 6
   洗涤washed with water and saturated sodium chloride solution
7. 7
   其他dried
8. 8
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
9. 9
   其他the brown residue was chromatographed through 500 g of silica gel

实验过程

The 8,9-difluoro-3-methyl-1,2,3,4-tetrahydro-1-oxaanthracene (1.5 g) obtained in this way was dissolved in 40 ml of tetrahydrofuran and admixed at −75° C. with 7 mmol of n-butyllithium. After stirring for a further 30 minutes, a solution of 7 mmol of potassium tert-butoxide in 20 ml of tetrahydrofuran was added dropwise. After cooling to −95° C., 15 mmol of propyl bromide were added dropwise. After 2 h, the temperature was cooled to −70° C., the mixture was stirred at this temperature for a further 1 h and was then allowed to come to 0° C. overnight. The mixture was added to 200 ml of ice-water and extracted twice with 100 ml each time of tert-butyl methyl ether, and the organic phases were combined, washed with water and saturated sodium chloride solution and dried. The solvent was distilled off under reduced pressure and the brown residue was chromatographed through 500 g of silica gel using heptane/toluene (9:1, v/v). 0.42 g of 8,9-difluoro-3-methyl-7-propyl-1,2,3,4-tetrahydro-1-oxaanthracene was obtained as a colorless syrup.

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