反应 #2255

反应方程式

N-(3-chloro-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine

ethylenediamine

→

N-(3-chloro-phenyl)-4-[2-(2-amino-ethyl-amino)-4-pyridyl]-2-pyrimidineamine

反应条件

后处理

1. 1
   浓缩Concentration and chromatography (methylene chloride:methanol:conc. ammonia solution=80:20: 1)

实验过程

20 mg (0.063 mmol) of N-(3-chloro-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine are stirred for 26 h at 110° with 1 ml of ethylenediamine. Concentration and chromatography (methylene chloride:methanol:conc. ammonia solution=80:20: 1) give N-(3-chloro-phenyl)-4-[2-(2-amino-ethyl-amino)-4-pyridyl]-2-pyrimidineamine; Rf =0.15 (methylene chloride:methanol:conc. ammonia solution=80:20:1), FAB-MS: 341 (M+ +1).

来源