反应 #2207265

反应方程式

EDC HOBT iPr2NEt

4-amino-2,6-dimethyl benzoic acid

→

4-[(ethylamino)carbonylamino]-2,6-dimethyl Benzoic Acid

反应条件

后处理

1. 1
   其他Purification via flash chromatography (2/1 hexanes/acetone, SiO2)
2. 2
   其他gave 1.16 g (52%) of 8AA as a yellow foam

实验过程

8AA: The tri-hydrochloride salt of the product of Example 8. step 3 (2 g, 4.3 mmol) and 4-amino-2,6-dimethyl benzoic acid (710 mg, 4.3 mmol) (see preparation below) were subjected to the standard coupling conditions (EDC/HOBT/iPr2NEt). Purification via flash chromatography (2/1 hexanes/acetone, SiO2) gave 1.16 g (52%) of 8AA as a yellow foam.

来源