反应 #2200634

反应方程式

5-fluoro-2-(4-methyl-imidazol-1-yl)-benzonitrile

Eschenmoser's salt

→

title compound

收率 34.0%

2-(5-Dimethylaminomethyl-4-methyl-imidazol-1-yl)-5-fluoro-benzonitrile

收率 34.0%

溶剂

DMF

反应条件

后处理

1. 1
   其他Evaporation of the solvent, aqueous workup and crystallization from Ethyl acetate/diisopropylether

实验过程

In analogy to example 5b, 5-fluoro-2-(4-methyl-imidazol-1-yl)-benzonitrile was reacted with Eschenmoser's salt in DMF for 24 h at 90° C. Evaporation of the solvent, aqueous workup and crystallization from Ethyl acetate/diisopropylether afforded the title compound as a white solid (yield: 34%). MS: m/e=259.2 [M+H]+.

来源