反应 #2200632

反应方程式

5-chloro-2-(4-methyl-imidazol-1-yl)-benzonitrile

Eschenmoser's salt

→

title compound

收率 17.0%

5-Chloro-2-(5-dimethylaminomethyl-4-methyl-imidazol-1-yl)-benzonitrile

收率 17.0%

溶剂

DMF

反应条件

后处理

1. 1
   其他Evaporation of the solvent, aqueous workup and crystallization from Ethyl acetate

实验过程

In analogy to example 5b, 5-chloro-2-(4-methyl-imidazol-1-yl)-benzonitrile was reacted with Eschenmoser's salt in DMF for 16 h at 90° C. Evaporation of the solvent, aqueous workup and crystallization from Ethyl acetate afforded the title compound as a white solid (yield: 17%). MS: m/e=275.1 [M+H]+.

来源