反应 #2200627

反应方程式

2-fluoro-5-trifluoromethoxy-benzaldehyde

hydroxylamine HCl

sodium acetate

→

title compound

收率 88.0%

E-2-Fluoro-5-trifluoromethoxy-benzaldehyde oxime

收率 88.0%

溶剂

ethanol

反应条件

后处理

1. 1
   温度The mixture was refluxed for 2 h
2. 2
   其他the solvent was evaporated
3. 3
   过滤The precipitate was filtered
4. 4
   其他dried
5. 5
   其他chromatographed (SiO2, heptanes:Ethyl acetate=100:0 to 80:2)

实验过程

A solution of 2-fluoro-5-trifluoromethoxy-benzaldehyde (9.78 g, 47 mmol) in ethanol (50 ml) was treated with hydroxylamine HCl (3.59 g, 52 mmol) and sodium acetate (4.27 g, 52 mmol). The mixture was refluxed for 2 h, the solvent was evaporated and the residue stirred with water (50 ml). The precipitate was filtered, dried and chromatographed (SiO2, heptanes:Ethyl acetate=100:0 to 80:2) and afforded the title compound (9.21 g, 88%) as a white solid. MS: m/e=223.0 [M]+.

来源