反应 #2200625

反应方程式

2-(4-methyl-imidazol-1-yl)-5-nitro-benzonitrile

Eschenmoser's salt

→

title compound

收率 35.0%

2-(5-Dimethylaminomethyl-4-methyl-imidazol-1-yl)-5-nitro-benzonitrile

收率 35.0%

溶剂

DMF

反应条件

后处理

1. 1
   其他Evaporation of the solvent, aqueous workup and chromatography

实验过程

In analogy to example 5b, 2-(4-methyl-imidazol-1-yl)-5-nitro-benzonitrile (+regioisomer) was reacted with Eschenmoser's salt in DMF for 16 h at 90° C. Evaporation of the solvent, aqueous workup and chromatography afforded the title compound as a yellow oil that was sufficiently pure to be used in the next step (yield: 35%). MS: m/e=286.1 [M+H]+.

来源