反应 #2200624

反应方程式

2-(5-methyl-imidazol-1-yl)-5-nitro-benzonitrile

2-fluoro-5-nitro-benzonitrile

4-methylimidazole

potassium carbonate

→

title compound

2-(4-Methyl-imidazol-1-yl)-5-nitro-benzonitrile

反应条件

后处理

1. 1
   其他Aqueous workup afforded

实验过程

In analogy to example 5a, 2-fluoro-5-nitro-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 1 h at 20° C. Aqueous workup afforded a 3.6:1 mixture of the title compound and its regioisomer [2-(5-methyl-imidazol-1-yl)-5-nitro-benzonitrile] as a light brown solid (yield: 69%). MS: m/e=229.4 [M+H]+.

来源