反应 #2200622

反应方程式

5-trifluoromethyl-2-(5-methyl-imidazol-1-yl)-benzonitrile

2-fluoro-5-(trifluoromethyl)-benzonitrile

4-methylimidazole

potassium carbonate

→

title compound

5-Trifluoromethyl-2-(4-methyl-imidazol-1-yl)-benzonitrile

反应条件

后处理

1. 1
   萃取After aqueous workup and extraction with Ethyl acetate
2. 2
   干燥the organic phase was dried (Na2SO4)
3. 3
   浓缩concentrated
4. 4
   其他to furnish

实验过程

In analogy to example 5a, 2-fluoro-5-(trifluoromethyl)-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 16 h at 90° C. After aqueous workup and extraction with Ethyl acetate, the organic phase was dried (Na2SO4) and concentrated to furnish a 3.4:1 mixture of the title compound and its regioisomer [5-trifluoromethyl-2-(5-methyl-imidazol-1-yl)-benzonitrile] as a light brown oil (yield: 85%). MS: m/e=252.3 [M+H]+.

来源