反应 #2200614

反应方程式

LiOH.H2O

5-chloro-1-cyanomethyl-1H-indole-2-carboxylic acid ethyl ester

→

desired product

收率 84.0%

5-Chloro-1-cyanomethyl-1H-indole-2-carboxylic acid

收率 84.0%

溶剂

THF H2O

反应条件

后处理

1. 1
   浓缩partially concentrated until precipitation of the crude product which
2. 2
   过滤was filtered off
3. 3
   洗涤washed with Et2O
4. 4
   其他dried

实验过程

To a solution of 1.0 eq. of 5-chloro-1-cyanomethyl-1H-indole-2-carboxylic acid ethyl ester (CAS 126718-08-9; prepared according to Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1989), 28B(12), 1065-8) in a mixture of THF/H2O ((9/1) was added LiOH.H2O (1.0 eq.) and the reaction mixture stirred 6 h at RT, acidified to pH 2 and then partially concentrated until precipitation of the crude product which was filtered off and washed with Et2O and then dried to give the desired product as a light yellow solid (84%).

来源