反应 #2200604

反应方程式

2-chloro-1-phenylethanol

4,5-dimethylthiazole

→

product

3-(2-Phenyl-2-hydroxyethyl)-4,5-dimethylthiazolium chloride

溶剂

water

反应条件

后处理

1. 1
   温度were heated
2. 2
   温度It was cooled to room temperature
3. 3
   workup.STIRRINGwith stirring
4. 4
   萃取was extracted with ether (30 mL)
5. 5
   workup.ADDITIONThe water layer was treated with actived carbon
6. 6
   其他evaporated to dryness
7. 7
   其他It was crystallized from a mixture of acetonitrile and ether

实验过程

The neat mixture of 2-chloro-1-phenylethanol (2.34 g, 14.9 mmol) and 4,5-dimethylthiazole (1.69 g, 14.9 mmol) were heated with stirring at 135° C. for 28 hrs. It was cooled to room temperature and water (30 mL) was added to the reaction mixture with stirring, and then was extracted with ether (30 mL). The water layer was treated with actived carbon and evaporated to dryness. It was crystallized from a mixture of acetonitrile and ether to give a racemic product as prisms; 0.39 g (9.7%); mp. 201-203° C.

来源