反应 #2200596

反应方程式

methyl 4-amino-3-chloro-5-fluoro-6-vinylpyridine-2-carboxylate

→

methyl 4-amino-3-chloro-6-ethyl-5-fluoropyridine-2-carboxylate

收率 76.9%

溶剂

ethanol

反应条件

后处理

1. 1
   其他for 1 hour
2. 2
   过滤The mixture was filtered through celite,
3. 3
   浓缩concentrated
4. 4
   其他the residue purified by column chromatography (50% ethyl acetate in hexane)

实验过程

A solution of methyl 4-amino-3-chloro-5-fluoro-6-vinylpyridine-2-carboxylate (3.00 g, 13.0 mmol) and 10% Pd/C (0.30 g) in ethanol (200 mL) was stirred under an atmosphere of hydrogen at 20 psi using a Parr apparatus for 1 hour. The mixture was filtered through celite, concentrated and the residue purified by column chromatography (50% ethyl acetate in hexane) to provide methyl 4-amino-3-chloro-6-ethyl-5-fluoropyridine-2-carboxylate (2.35 g, 10.0 mmol), mp 109-110° C.

来源