反应 #2200592

反应方程式

hydrochloric acid

phenylpyruvic acid

oxalacetic acid

potassium hydroxide

→

4-phenylmethyl-4-hydroxy-2-ketoglutaric acid

收率 37.0%

溶剂

water

反应条件

后处理

1. 1
   其他to react at room temperature for 72 hours
2. 2
   萃取extracted with ethyl acetate
3. 3
   洗涤The organic layer was washed with saturated brine
4. 4
   干燥dried on anhydrous magnesium sulfate, and condensed
5. 5
   其他to yield a residue
6. 6
   其他This was recrystallized from ethyl acetate and toluene

实验过程

To a solution of 13.8 g of potassium hydroxide (85% purity) dissolved in 25 ml of water were added 5.0 g (30.5 mmol) of phenylpyruvic acid and 12.1 g (91.4 mmol) of oxalacetic acid, and the mixture was allowed to react at room temperature for 72 hours. The reaction mixture was adjusted at pH 2.2 with conc. hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried on anhydrous magnesium sulfate, and condensed to yield a residue. This was recrystallized from ethyl acetate and toluene to yield 2.8 g (11.3 mmol) of 4-phenylmethyl-4-hydroxy-2-ketoglutaric acid as crystals.

来源