反应 #2200591

ord-1fff50506c2a4a5d944f955940948bea

反应方程式

O=C(O)C(=O)Cc1ccccc1
phenylpyruvic acid
CC(=O)C(=O)O
pyruvic acid
O=C(O)C(=O)CC(O)(Cc1ccccc1)C(=O)O
4-phenylmethyl-4-hydroxy-2-oxoglutaric acid

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

According to the study by the present inventors, it has been found that PtALD can catalyze the aldol condensation reaction of indolepyruvic acid with pyruvic acid (or oxalacetic acid) to yield 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid (IHOG), and the reaction of phenylpyruvic acid with pyruvic acid to yield 4-phenylmethyl-4-hydroxy-2-oxoglutaric acid (PHOG).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07432100B2uspto-grants-2008_10