反应 #2195497

反应方程式

diethyl 3-oxopentanedioate

sodium bicarbonate

Lawesson's reagent

→

title compound

Diethyl 3-thioxopentanedioate

溶剂

toluene

反应条件

后处理

1. 1
   温度then heat
2. 2
   温度under reflux for 5 h
3. 3
   温度Cool
4. 4
   过滤filter
5. 5
   浓缩concentrate in vacuo
6. 6
   其他Purify the residue by silica gel chromatography

实验过程

Dissolve 14.1 mmol of diethyl 3-oxopentanedioate in 15 mL of toluene under argon add 49.4 mmol of sodium bicarbonate and 15.1 mmol of Lawesson's reagent. Stir for 1 h at room temperature then heat under reflux for 5 h. Cool, filter, and concentrate in vacuo. Purify the residue by silica gel chromatography using ethyl acetate/hexanes eluant to yield the title compound.

来源