反应 #2195473

反应方程式

phenol

sodium hydride

HCl

→

Dibenzofuran

溶剂

DMSO

反应条件

后处理

1. 1
   萃取The aqueous phase is extracted with MTB ether
2. 2
   干燥The organic phase is dried over sodium sulfate
3. 3
   其他evaporated
4. 4
   其他chromatographed on silica gel

实验过程

The phenol 10 is dissolved in DMSO under nitrogen, a 60% sodium hydride/mineral oil suspension is added, and the mixture is warmed to 120° C. After 5 hours at this temperature, the cooled batch is added to dil. HCl solution. The aqueous phase is extracted with MTB ether. The organic phase is dried over sodium sulfate, evaporated and chromatographed on silica gel.

来源