反应 #2193

反应方程式

4-chloro-4'-mercaptomethylbenzophenone

ethyl bromide

potassium hydroxide

→

desired product

收率 79.1%

4-Chloro-4'-ethylthiomethylbenzophenone

收率 79.1%

溶剂

methanol

反应条件

后处理

1. 1
   温度under reflux
2. 2
   浓缩concentrated
3. 3
   workup.ADDITIONWater was added to the residue
4. 4
   萃取the mixture was extracted with ethyl acetate
5. 5
   洗涤The ethyl acetate layer was washed with water
6. 6
   干燥dried over anhydrous magnesium sulfate
7. 7
   浓缩concentrated
8. 8
   其他The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=10:1)

实验过程

4-chloro-4'-mercaptomethylbenzophenone (16.0 g), ethyl bromide (7.4 g) and potassium hydroxide (4.3 g) were added to methanol (250 ml), and the mixture was stirred for 30 minutes under reflux. The reaction mixture was cooled to room temperature and then concentrated. Water was added to the residue, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and then dried over anhydrous magnesium sulfate and concentrated. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=10:1) to obtain the desired product 14.0 g, melting point: 33° to 34° C., yield: 79%).

来源