反应 #2192498

反应方程式

2-chloro-5-bromo-3H-pyrimidin-4-one

5-bromo-2-chloro-3H-pyrimidin-4-one

2-bromomethyl-thiophene-3-carbonitrile

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title compound

收率 58.0%

2-(5-Bromo-2-chloro-6-oxo-6H-pyrimidin-1ylmethyl)-thiophene-3-carbonitrile

收率 58.0%

反应条件

实验过程

The title compound was prepared in 58% yield from 2-chloro-5-bromo-3H-pyrimidin-4-one (Example 1A) and 2-bromomethyl-thiophene-3-carbonitrile according to the general procedure outlined for Example 1B. 1H NMR (400 MHz, CDCl3): δ 8.10 (s, 1H), 7.40 (d, 1H, J=5.6 Hz), 7.21 (d, 1H, J=5.6 Hz), 5.74 (s, 2H). MS (ES) [m+H] calc'd for C10H5N3OSBrCl, 330, 332; found 330, 332.

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