反应 #218850

反应方程式

N-(2-Methoxy-5-nitrobenzyl)acetamide 2-Acetamidomethyl-4-nitrophenol

sodium carbonate

iodomethane

→

N-(2-methoxy-5-nitrobenzyl)acetamide

溶剂

acetone

反应条件

后处理

1. 1
   温度at reflux 4 h
2. 2
   过滤The mixture was filtered
3. 3
   其他the filtrate evaporated to dryness
4. 4
   温度The residue was warmed with aqueous sodium carbonate
5. 5
   洗涤washed with water
6. 6
   其他dried
7. 7
   其他Crystallised from ethanol/dilute acetic acid

实验过程

N-(2-Methoxy-5-nitrobenzyl)acetamide 2-Acetamidomethyl-4-nitrophenol (2 g), sodium carbonate (2 g) and iodomethane (2 ml) were stirred in acetone (30 ml) at reflux 4 h. The mixture was filtered, the filtrate evaporated to dryness. The residue was warmed with aqueous sodium carbonate, washed with water and dried. Crystallised from ethanol/dilute acetic acid to give N-(2-methoxy-5-nitrobenzyl)acetamide as buff prisms. MP: 158.5-159.5° C.

来源