反应 #2186169

反应方程式

acetone

sulfuric acid

L-ascorbic acid

→

5,6-O-isopropylidene-L-ascorbic acid

收率 115.4%

反应条件

后处理

1. 1
   其他The mixture was then reacted at the temperature of the previous step for 17 hours
2. 2
   过滤filtered
3. 3
   洗涤washed with cold acetone

实验过程

With nitrogen substitution, 557.8 grams (9.6 moles) of acetone was cooled to −5 degrees C., 54.3 grams (0.2 moles) of 28% fuming sulfuric acid was dripped, and 176.1 grams (1.0 mole) of L-ascorbic acid was added. The mixture was then reacted at the temperature of the previous step for 17 hours, filtered and washed with cold acetone to obtain 249.5 grams of 5,6-O-isopropylidene-L-ascorbic acid (86.7% in purity) in the form of a wet cake.

来源