反应 #218454

反应方程式

trans-4-(aminomethyl)cyclohexanecarboxylic acid

methanol

thionyl chloride

→

methyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride

反应条件

后处理

1. 1
   温度cooling
2. 2
   浓缩The reaction mixture is concentrated in vacuo

实验过程

To a suspension of trans-4-(aminomethyl)cyclohexanecarboxylic acid (6.29 g) in methanol (32 mL) is added dropwise thionyl chloride (6 mL) under ice-cooling and the mixture is stirred at room temperature overnight. The reaction mixture is concentrated in vacuo to give methyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride (8.69 g). MS (APCI) m/z: 172 [M+H]+

来源