反应 #217909

ord-c4c971771780439a921d06f9270a3a46

反应方程式

NC(=O)c1ccc(Oc2ccc(C=O)cc2F)nc1
compound
NC(=O)c1ccc(Oc2ccc(C=O)cc2F)nc1
6-(2-Fluoro-4-formyl-phenoxy)-nicotinamide
CC(C)CCN
3-methylbutylamine
CC(C)CCNCc1ccc(Oc2ccc(C(N)=O)cn2)c(F)c1
title compound
收率 99.0%
CC(C)CCNCc1ccc(Oc2ccc(C(N)=O)cn2)c(F)c1
6-[2-Fluoro-4-(3-methyl-butylamino-methyl)-phenoxy]nicotinamide
收率 99.0%

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

Using the compound of Example 223, step 1, and using 3-methylbutylamine, the title compound was prepared by reductive amination as described previously.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07381719B2uspto-grants-2008_06